Embryonic Stem Cells Kill

[me]

Embryonic Stem Cells Kill

Thursday, March 12, 2009 11:05 AM

By: Michael Reagan    Article Font Size 

What President Obama did when he reversed President Bush's executive order banning embryonic stem cell research was based not on solid science, but his desire to cater to the anti-life, pro-abortion forces and their media allies who helped elect him.

In doing this, he created the potential for an outbreak of potentially fatal cancerous tumors caused by the therapeutic use of embryonic stem cells.

Moreover, he killed another Bush presidential order that funded some of the most promising research on the creation of embryonic-like stem cells from harmless but potent adult stem cells.

What President Obama did when he rescinded President Bush's federal ban on certain lines of embryonic stem cell research ultimately could cost American lives.

Obama and his subservient mainstream media allies ignored science in favor of politics, and the results will prove to be disastrous.

What most people are unaware of is that there are three types of stem cell research: there is embryonic stem cell research (ESC), there is induced pluripotent (IPSC) research, and adult stem cell research (ASC).

When Barack Obama rescinded George Bush's ban on federal funding on certain types of embryonic stem cell research he also rescinded Bush's Executive Order 13435 that had provided federal funding for induced pluripotent stem cell research using harmless adult stem cells manipulated into mimicking embryonic stem cells without the risk ESC cells entail.

This is where 72 different diseases are now being remedied or cured.

There are no embryonic stem cells being used anywhere in the world on humans, with one tragic exception. A boy treated with embryonic stem cells for a rare genetic disease developed benign tumors, casting doubt on claims of the therapy's safety and effectiveness.

According to media reports, the boy, now 17, received the ESC stem cells in 2001 at a Moscow hospital and four years later scans showed brain and spinal tumors. Israeli doctors removed the abnormal growth from his spine and their tests show it most probably was caused by the stem cells.

The Moscow doctors should have known better. It is well known that lab animals given embryonic stem cells routinely develop tumors and other malignant growths that eventually kill them. There is a 100 percent mortality rate among lab animals that develop these tumors.

That's why George Bush banned this lethal form of research that Barack Obama, who should have known better, has now legitimized by overturning this life-saving ban.

The reason that major drug companies such as Merck and Pfizer are not funding ESC research is because they have seen the research and it scared the daylights out of them. They realized that if they injected ESC cells into human beings and like lab animals, they show signs of cancers or lesions or tumors there will be huge class action suits, because they would have ignored all of the available data in research that shows that that's exactly what will happen.

The fact of the matter is embryonic stem cells kill. The research shows conclusively that they help rats and mice die and an Israeli boy grow tumors.

Barack Obama rescinded Bush's executive order banning this dangerous research, which has failed everywhere it has been tried, and then went on to eliminate funding for some of the most promising research on the use of pluripotent adult stem cells.

Unfortunately, those opposed to these actions have made the mistake of concentrating on the pro-life aspects of this controversy, while ignoring the scientific aspects, which prove our case conclusively.

We can win this case, by concentrating on the science, which is on our side.

Anyone who is willing to inject embryonic stem cell into their bodies needs to understand that -- like the Israeli boy and the lab animals-- they will grow tumors and lesions.

http://www.newsmax.com/reagan/reagan_stem_cells_kill/2009/03/12/191214.html

[Palehorse]

 

[followsthewolf]

 

[Henry Hawk]

not on solid science, but his desire to cater to the anti-life, pro-abortion forces and their media allies who helped elect him

....

That is a very true statement...

[Exterminator]

Anyone who believes this tripe should have been an abortion.   

[me]

Here are some articles:
http://www.stemcellresearchfacts.com/

Had to subscribe to get this one so it might not work:
http://www.sciencemag.org/cgi/content/full/318/5858/1917

Originally published in Science Express on 20 November 2007
Science 21 December 2007:
Vol. 318. no. 5858, pp. 1917 - 1920
DOI: 10.1126/science.1151526
   
Prev | Table of Contents | Next
Reports
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,1,2* Maxim A. Vodyanik,2 Kim Smuga-Otto,1,2 Jessica Antosiewicz-Bourget,1,2 Jennifer L. Frane,1 Shulan Tian,3 Jeff Nie,3 Gudrun A. Jonsdottir,3 Victor Ruotti,3 Ron Stewart,3 Igor I. Slukvin,2,4 James A. Thomson1,2,5*

Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful in the production of new disease models and in drug development, as well as for applications in transplantation medicine, once technical limitations (for example, mutation through viral integration) are eliminated.

1 Genome Center of Wisconsin, Madison, WI 53706–1580, USA.
2 Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715–1299, USA.
3 WiCell Research Institute, Madison, WI 53707–7365, USA.
4 Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
5 Department of Anatomy, University of Wisconsin-Madison, Madison, WI 53706–1509, USA.

* To whom correspondence should be addressed. E-mail: jyu@primate.wisc.edu (J.Y.); thomson@primate.wisc.edu (J.A.T.)

Mammalian embryogenesis elaborates distinct developmental stages in a strict temporal order. Nonetheless, because development is dictated by epigenetic rather than genetic events, differentiation is, in principle, reversible. The cloning of Dolly demonstrated that nuclei from mammalian differentiated cells can be reprogrammed to an undifferentiated state by trans-acting factors present in the oocyte (1), and this discovery led to a search for factors that could mediate similar reprogramming without somatic cell nuclear transfer. Recently, four transcription factors (Oct4, Sox2, c-myc, and Klf4) were shown to be sufficient to reprogram mouse fibroblasts to undifferentiated, pluripotent stem cells [termed induced pluripotent stem (iPS) cells] (2–5). Reprogramming human cells by defined factors would allow the generation of patient-specific pluripotent cell lines without somatic cell nuclear transfer, but the observation that the expression of c-Myc causes death and differentiation of human ES cells suggests that combinations of factors lacking this gene are required to reprogram human cells (6). We demonstrate that OCT4, SOX2, NANOG, and LIN28 are sufficient to reprogram human somatic cells.

Human ES cells can reprogram myeloid precursors through cell fusion (7). To identify candidate reprogramming factors, we compiled a list of genes with enriched expression in human ES cells relative to that of myeloid precursors and prioritized the list based on known involvement in the establishment or maintenance of pluripotency (table S1). We then cloned these genes into a lentiviral vector (fig. S1) to screen for combinations of genes that could reprogram the differentiated derivatives of an OCT4 knock-in human ES cell line generated through homologous recombination (8.). In this cell line, the expression of neomycin phosphotransferase, which makes cells resistant to geneticin, is driven by an endogenous OCT4 promoter, a gene that is highly expressed in pluripotent cells but not in differentiated cells. Thus, reprogramming events reactivating the OCT4 promoter can be recovered by geneticin selection. The first combination of 14 genes that we selected (table S2) directed the reprogramming of adherent cells, which were derived from human ES cell–derived CD45+ hematopoietic cells (7, 9), to geneticin-resistant (OCT4+) colonies with an ES cell morphology (fig. S2A) (10). These geneticin-resistant colonies expressed typical human ES cell–specific cell surface markers (fig. S2B) and formed teratomas when injected into immunocompromised severe combined immunodeficient–beige mice (fig. S2C).

By testing subsets of the 14 initial genes, we identified a core set of 4 genes, OCT4, SOX2, NANOG, and LIN28, that were capable of reprogramming human ES cell–derived somatic cells with a mesenchymal phenotype (Fig. 1A and fig. S3). Removal of either OCT4 or SOX2 from the reprogramming mixture eliminated the appearance of geneticin-resistant (OCT4+) reprogrammed mesenchymal clones (Fig. 1A). NANOG showed a beneficial effect in clone recovery from human ES cell–derived mesenchymal cells but was not required for the initial appearance of such clones (Fig. 1A). These results are consistent with cell fusion–mediated reprogramming experiments, where overexpression of Nanog in mouse ES cells resulted in over a 200-fold increase in reprogramming efficiency (11). The expression of NANOG also improves the cloning efficiency of human ES cells (12) and thus could increase the survival rate of early reprogrammed cells. LIN28 had a consistent but more modest effect on reprogrammed mesenchymal cell clone recovery (Fig. 1A).

Here is the link that lead me to the above:
http://www.sciencemag.org/cgi/content/abstract/1151526

[xman]

With my serious back injuries...and associated medical problems...embronic stem cell research is my best chance at resuming a life that was filled with quality. Meanwhile, I will just wallow in the depression that medical infirmities engender. Too bad we had to wait eight years to get scince back on track.

[me]

With my serious back injuries...and associated medical problems...embronic stem cell research is my best chance at resuming a life that was filled with quality. Meanwhile, I will just wallow in the depression that medical infirmities engender. Too bad we had to wait eight years to get scince back on track.

But the other stem cell research has been proven to work and is, it would seem, a lot safer.  It has already been used on humans and has proven to be effective whereas the embryonic stem cells have produced tumorous growths and not been as effective.  Research was never stopped on the other type of stem cell research but has been ongoing.

[mcgonser]

Thats right, stem cell research has already helped a lot. They think they have found the cure for MS, diabeties and others. This is without the embryo stem cells. hmmmmmmmm

[Exterminator]

Who knows what they might have accomplished by now if they hadn't been hindered.  Heck, they might have even been able to teach mcgonser how to spell 'diabetes'!

[mcgonser]

I no that u are so smart and perfect EX: it must b hard too have too be with someone so stupid. Gee I feel real real real real real sorry fur u.

[Exterminator]

I can't help it; my grandmother was an English teacher.   

[mcgonser]

Its a shame that someone in your family didn't teach you tact and consideration.

[Exterminator]

Its a shame that someone in your family didn't teach you tact and consideration.

My but aren't you the self-righteous one.

[mcgonser]

Actually no: I just don't feel compelled to correct everyone on their spelling or grammar. Must be a flaw in me.